Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4⁺ T cells through differential DNA methylation, explaining a substantial proportion of heritability

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis

BACKGROUND Regulatory T cells (Tregs) have important functions in peripheral immune tolerance. Dysfunction of Tregs is considered to be a pivotal cause of autoimmune diseases, including rheumatoid arthritis (RA). However, previous reports describing the proportion of Tregs among CD4+ T cells in RA patients were controversial because a range of markers are used to identify Tregs with little cons...

T cells in rheumatoid arthritis

Over the past decade and a half, advances in our understanding of the pathogenesis of immune-mediated diseases such as rheumatoid arthritis (RA) have translated directly into benefit for patients. Much of this benefit has arisen through the introduction of targeted biological therapies. At the same time, technological advances have made it possible to define, at the cellular and molecular level...

Rheumatoid Arthritis Synoviocytes Regulation of DNA Methylation in

Role of T cells in rheumatoid arthritis

This review focuses on the contributions made by interactions between dendritic cells (DCs) and T cells, and by local production of cytokines and chemokines to the pathogenesis of rheumatoid arthritis (RA) synovitis. DCs are efficient professional antigenpresenting cells, which are critical for the development of innate and adaptative immune responses through interactions with T cells. Cytokine...

DDNMT3B Variants Regulate DNA Methylation in a Promoter-Specific Manner

DNA methyltransferase 3B (DNMT3B) is critical in de novo DNA methylation during development and tumorigenesis. We recently reported the identification of a DNMT3B subfamily, #DNMT3B, which contains at least seven variants, resulting from alternative pre-mRNA splicing. DDNMT3Bs are the predominant expression forms of DNMT3B in human lung cancer. A strong correlation was observed between the prom...